Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats

Abstract Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divide...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2013-10, Vol.47 (5), p.355-360
Main Authors: Babri, Shirin, Amani, Mohammad, Mohaddes, Gisou, Mirzaei, Fariba, Mahmoudi, Fariba
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Convulsants
Disease Models, Animal
Endocrinology & Metabolism
Ghrelin
Ghrelin - administration & dosage
Ghrelin - pharmacology
Hippocampus
Hippocampus - drug effects
Injections
Learning
Male
Maze Learning - drug effects
Memory - drug effects
Morris water maze
Pentylenetetrazol (PTZ)
Pentylenetetrazole
Rats
Rats, Wistar
Seizures - chemically induced
Seizures - physiopathology
Spatial Behavior - drug effects
Spatial memory
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Summary:Abstract Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and pentylenetetrazol (PTZ, 50 mg/kg, i.p.) plus saline or ghrelin (0.3, 1.5 or 3 nmol). All groups were trained in Morris water maze (MWM) for two consecutive days. Our results showed that ghrelin significantly improves spatial memory at the doses of 1.5 or 3 nmol ( P < 0.05) in normal rats. We also demonstrated the significant impairment of spatial memory in PTZ group ( P < 0.05). Intrahippocampal injection of ghrelin at the dose of 3 nmol significantly improved spatial memory in PTZ + gh group compared to PTZ group ( P < 0.05). These findings suggest that ghrelin as a neuropeptide can improve spatial memory in PTZ-treated rats.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2013.05.005