Directed Migration in Neural Tissue Engineering

Directed cell migration is particularly important in neural tissue engineering, where the goal is to direct neurons and support cells across injured nerve gaps. Investigation of the gradients present in the body during development provides an approach to guiding cells in peripheral and central nervo...

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Published in:Tissue engineering. Part B, Reviews Reviews, 2014-04, Vol.20 (2), p.93-105
Main Authors: Wrobel, Melissa R., Sundararaghavan, Harini G.
Format: Article
Language:English
Subjects:
Animals
Cell adhesion & migration
Cell Movement - physiology
Humans
Neural networks
Neurons - cytology
Tissue engineering
Tissue Engineering - methods
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Sundararaghavan, Harini G.
description Directed cell migration is particularly important in neural tissue engineering, where the goal is to direct neurons and support cells across injured nerve gaps. Investigation of the gradients present in the body during development provides an approach to guiding cells in peripheral and central nervous system tissue, but many different types of gradients and patterns can accomplish directed migration. The focus of this review is to describe current research paradigms in neural tissue gradients and review their effectiveness for directed migration. The review explores directed migration achieved through the use of chemical, adhesive, mechanical, topographical, and electrical types of gradients. Few studies investigate combined gradients, though it is known that a combination of therapies is necessary for reconnection of neuronal circuitry. To date, there has been no systematic review of gradient approaches to neural tissue engineering. By looking at effectiveness of various scaffold cue presentation and methods to combine these strategies, the potential for nerve repair is increased.
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source 美国Mary Ann Liebert出版公司期刊（NSTL购买）
subjects Animals
Cell adhesion & migration
Cell Movement - physiology
Humans
Neural networks
Neurons - cytology
Tissue engineering
Tissue Engineering - methods
title Directed Migration in Neural Tissue Engineering
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