Safety and immunogenicity of inactivated poliovirus vaccine based on Sabin strains with and without aluminum hydroxide: A phase I trial in healthy adults

Highlights • Both Sabin-IPV and Sabin-IPV adjuvanted with aluminum hydroxide are well-tolerated. • A booster with Sabin-IPV or adjuvanted Sabin-IPV is equally immunogenic as conventional IPV. • Sabin-IPV induces virus neutralizing titers against both Sabin and wild poliovirus strains.

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Bibliographic Details
Published in:Vaccine 2013-11, Vol.31 (47), p.5531-5536
Main Authors: Verdijk, Pauline, Rots, Nynke Y, van Oijen, Monique G.C.T, Oberste, M. Steven, Boog, Claire J, Okayasu, Hiromasa, Sutter, Roland W, Bakker, Wilfried A.M
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants, Immunologic - administration & dosage
Adolescent
Adult
adults
Allergy and Immunology
Aluminum
Aluminum hydroxide
Aluminum Hydroxide - administration & dosage
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Applied microbiology
Biological and medical sciences
Body temperature
Double-Blind Method
Family medical history
Fundamental and applied biological sciences. Psychology
Health care
Healthy Volunteers
Humans
immune response
Immune system
Immunogenicity
Inactivated poliovirus vaccine
income
Injections, Intramuscular
intramuscular injection
Low income groups
Male
Microbiology
Middle Aged
Miscellaneous
Phase I trial
Poliomyelitis
Poliomyelitis - prevention & control
Poliovirus
Poliovirus Vaccine, Inactivated - administration & dosage
Poliovirus Vaccine, Inactivated - adverse effects
Poliovirus Vaccine, Inactivated - immunology
Sabin strains
Safety
Technology transfer
vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
Young Adult
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Description
Summary:Highlights • Both Sabin-IPV and Sabin-IPV adjuvanted with aluminum hydroxide are well-tolerated. • A booster with Sabin-IPV or adjuvanted Sabin-IPV is equally immunogenic as conventional IPV. • Sabin-IPV induces virus neutralizing titers against both Sabin and wild poliovirus strains.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.09.021