Analysis of parameters for the automatic computation of the tear film break-up time test based on CCLRU standards

Abstract Dry eye syndrome is affecting a remarkable percentage of population. The prevalence is 10–15% of normal population, and 18–30% of contact lenses users. The break-up time (BUT) is a clinical test used for the diagnosis of this disease. In this work, we perform an analysis of parameters for a...

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Bibliographic Details
Published in:Computer methods and programs in biomedicine 2014-03, Vol.113 (3), p.715-724
Main Authors: Ramos, L, Barreira, N, Mosquera, A, Penedo, M.G, Yebra-Pimentel, E, García-Resúa, C
Format: Article
Language:English
Subjects:
Adult
Algorithms
Applied sciences
Artificial intelligence
Biological and medical sciences
BUT test
Computational Biology
Computer science
control theory
systems
Databases, Factual
Diagnosis, Computer-Assisted - methods
Diagnosis, Computer-Assisted - standards
Diagnosis, Computer-Assisted - statistics & numerical data
Diagnostic Techniques, Ophthalmological - standards
Diagnostic Techniques, Ophthalmological - statistics & numerical data
Dry eye syndrome
Dry Eye Syndromes - diagnosis
Dry Eye Syndromes - physiopathology
Exact sciences and technology
Fluorescein
Fluorescent Dyes
Humans
Image processing
Internal Medicine
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Microscopy, Fluorescence
Microscopy, Video
Ophthalmology
Other
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pattern recognition. Digital image processing. Computational geometry
Tear film
Tears - chemistry
Tears - physiology
Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
Video analysis
Young Adult
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Description
Summary:Abstract Dry eye syndrome is affecting a remarkable percentage of population. The prevalence is 10–15% of normal population, and 18–30% of contact lenses users. The break-up time (BUT) is a clinical test used for the diagnosis of this disease. In this work, we perform an analysis of parameters for a global and a local automatic computation of the BUT measure, based on criteria of specificity and sensitivity. We have tested our methodology on a dataset composed of 18 videos annotated by 4 different experts. The local analysis preserves the results of the global approach providing useful additional information about the break-up tear zone.
ISSN:0169-2607
1872-7565
DOI:10.1016/j.cmpb.2013.12.003