Clinical significance of serum triple monoclonal components: A report of 6 cases and a review of the literature

Abstract A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia...

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Bibliographic Details
Published in:Leukemia research 2014-02, Vol.38 (2), p.166-169
Main Authors: Guastafierro, Salvatore, Sica, Antonello, Parascandola, Rita Rosaria, Ferrara, Maria Giovanna, Di Martino, Anna, Pezone, Luciano, Falcone, Umberto
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antibodies, Monoclonal - blood
Cancer
Diagnosis
Female
Hematology, Oncology and Palliative Medicine
Humans
Immunofixation
Intracellular immunofluorescence
Lymphoma, Non-Hodgkin - blood
Lymphoma, Non-Hodgkin - diagnosis
Lymphoproliferative disorders
Lymphoproliferative Disorders - blood
Lymphoproliferative Disorders - diagnosis
Male
Polycythemia Vera - blood
Polycythemia Vera - diagnosis
Serum electrophoresis
Triple monoclonal component
Waldenstrom Macroglobulinemia - blood
Waldenstrom Macroglobulinemia - diagnosis
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Summary:Abstract A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6 + 43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2013.10.020