Opioid system genes in alcoholism: A case–control study in Croatian population

Abstract Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their li...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2013-10, Vol.47 (5), p.315-319
Main Authors: Cupic, B, Stefulj, J, Zapletal, E, Matosic, A, Bordukalo-Niksic, T, Cicin-Sain, L, Gabrilovac, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Advanced Basic Science
Aged
Alcohol dependence
Alcoholism
Alcoholism - genetics
Case-Control Studies
Cloninger typology
Croatia
Endocrinology & Metabolism
Enkephalins - genetics
Genetic Association Studies
Humans
Male
Middle Aged
OPRK1
OPRM1
PDYN
Polymorphism, Single Nucleotide
POMC
Pro-Opiomelanocortin - genetics
Protein Precursors - genetics
Receptors, Opioid, kappa - genetics
Receptors, Opioid, mu - genetics
Single nucleotide polymorphism
Young Adult
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Summary:Abstract Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their ligands – proopiomelanocortin ( POMC ), coding for beta-endorphin and prodynorphin ( PDYN ) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2013.08.002