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Opioid system genes in alcoholism: A case–control study in Croatian population
Abstract Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their li...
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| Published in: | Neuropeptides (Edinburgh) 2013-10, Vol.47 (5), p.315-319 |
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| cites | cdi_FETCH-LOGICAL-c477t-86d49dc692655254e909e01010c09bb60fe7ce2bc60da981b1d7414749098cce3 |
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| container_title | Neuropeptides (Edinburgh) |
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| creator | Cupic, B Stefulj, J Zapletal, E Matosic, A Bordukalo-Niksic, T Cicin-Sain, L Gabrilovac, J |
| description | Abstract Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their ligands – proopiomelanocortin ( POMC ), coding for beta-endorphin and prodynorphin ( PDYN ) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population. |
| doi_str_mv | 10.1016/j.npep.2013.08.002 |
| format | article |
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In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their ligands – proopiomelanocortin ( POMC ), coding for beta-endorphin and prodynorphin ( PDYN ) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population.</description><identifier>ISSN: 0143-4179</identifier><identifier>EISSN: 1532-2785</identifier><identifier>DOI: 10.1016/j.npep.2013.08.002</identifier><identifier>PMID: 24035285</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Advanced Basic Science ; Aged ; Alcohol dependence ; Alcoholism ; Alcoholism - genetics ; Case-Control Studies ; Cloninger typology ; Croatia ; Endocrinology & Metabolism ; Enkephalins - genetics ; Genetic Association Studies ; Humans ; Male ; Middle Aged ; OPRK1 ; OPRM1 ; PDYN ; Polymorphism, Single Nucleotide ; POMC ; Pro-Opiomelanocortin - genetics ; Protein Precursors - genetics ; Receptors, Opioid, kappa - genetics ; Receptors, Opioid, mu - genetics ; Single nucleotide polymorphism ; Young Adult</subject><ispartof>Neuropeptides (Edinburgh), 2013-10, Vol.47 (5), p.315-319</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-86d49dc692655254e909e01010c09bb60fe7ce2bc60da981b1d7414749098cce3</citedby><cites>FETCH-LOGICAL-c477t-86d49dc692655254e909e01010c09bb60fe7ce2bc60da981b1d7414749098cce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24035285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cupic, B</creatorcontrib><creatorcontrib>Stefulj, J</creatorcontrib><creatorcontrib>Zapletal, E</creatorcontrib><creatorcontrib>Matosic, A</creatorcontrib><creatorcontrib>Bordukalo-Niksic, T</creatorcontrib><creatorcontrib>Cicin-Sain, L</creatorcontrib><creatorcontrib>Gabrilovac, J</creatorcontrib><title>Opioid system genes in alcoholism: A case–control study in Croatian population</title><title>Neuropeptides (Edinburgh)</title><addtitle>Neuropeptides</addtitle><description>Abstract Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their ligands – proopiomelanocortin ( POMC ), coding for beta-endorphin and prodynorphin ( PDYN ) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Aged</subject><subject>Alcohol dependence</subject><subject>Alcoholism</subject><subject>Alcoholism - genetics</subject><subject>Case-Control Studies</subject><subject>Cloninger typology</subject><subject>Croatia</subject><subject>Endocrinology & Metabolism</subject><subject>Enkephalins - genetics</subject><subject>Genetic Association Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>OPRK1</subject><subject>OPRM1</subject><subject>PDYN</subject><subject>Polymorphism, Single Nucleotide</subject><subject>POMC</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Protein Precursors - genetics</subject><subject>Receptors, Opioid, kappa - genetics</subject><subject>Receptors, Opioid, mu - genetics</subject><subject>Single nucleotide polymorphism</subject><subject>Young Adult</subject><issn>0143-4179</issn><issn>1532-2785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNks1u1DAURi1ERaeFF2CBsmSTcO34LwghVSMoSJWKBKytxLkDHhI72AnS7HiHviFPgqMpLFjQruzF-T7Z91xCnlKoKFD5Yl_5CaeKAa0r0BUAe0A2VNSsZEqLh2QDlNclp6o5JWcp7QGAM60fkVPGoRZMiw35cD254PoiHdKMY_EFPabC-aIdbPgaBpfGl8VFYduEv37e2ODnGIYizUt_WKltDO3sWl9MYVqGfA3-MTnZtUPCJ7fnOfn89s2n7bvy6vry_fbiqrRcqbnUsudNb2XDpBBMcGygQcjfAgtN10nYobLIOiuhbxtNO9orTrnimdPWYn1Onh97pxi-L5hmM7pkcRhaj2FJhgoqlaiVUHejPL-CMuDNPdCVlUrSjLIjamNIKeLOTNGNbTwYCmb1Y_Zm9WNWPwa0yX5y6Nlt_9KN2P-N_BGSgVdHAPPsfjiMJlmH3mLvItrZ9MH9v__1P3E7OO9sO3zDA6Z9WKLPVgw1iRkwH9cNWReE1nk5ZM3q37mHtUs</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Cupic, B</creator><creator>Stefulj, J</creator><creator>Zapletal, E</creator><creator>Matosic, A</creator><creator>Bordukalo-Niksic, T</creator><creator>Cicin-Sain, L</creator><creator>Gabrilovac, J</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20131001</creationdate><title>Opioid system genes in alcoholism: A case–control study in Croatian population</title><author>Cupic, B ; Stefulj, J ; Zapletal, E ; Matosic, A ; Bordukalo-Niksic, T ; Cicin-Sain, L ; Gabrilovac, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-86d49dc692655254e909e01010c09bb60fe7ce2bc60da981b1d7414749098cce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Aged</topic><topic>Alcohol dependence</topic><topic>Alcoholism</topic><topic>Alcoholism - genetics</topic><topic>Case-Control Studies</topic><topic>Cloninger typology</topic><topic>Croatia</topic><topic>Endocrinology & Metabolism</topic><topic>Enkephalins - genetics</topic><topic>Genetic Association Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>OPRK1</topic><topic>OPRM1</topic><topic>PDYN</topic><topic>Polymorphism, Single Nucleotide</topic><topic>POMC</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Protein Precursors - genetics</topic><topic>Receptors, Opioid, kappa - genetics</topic><topic>Receptors, Opioid, mu - genetics</topic><topic>Single nucleotide polymorphism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cupic, B</creatorcontrib><creatorcontrib>Stefulj, J</creatorcontrib><creatorcontrib>Zapletal, E</creatorcontrib><creatorcontrib>Matosic, A</creatorcontrib><creatorcontrib>Bordukalo-Niksic, T</creatorcontrib><creatorcontrib>Cicin-Sain, L</creatorcontrib><creatorcontrib>Gabrilovac, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Neuropeptides (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cupic, B</au><au>Stefulj, J</au><au>Zapletal, E</au><au>Matosic, A</au><au>Bordukalo-Niksic, T</au><au>Cicin-Sain, L</au><au>Gabrilovac, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opioid system genes in alcoholism: A case–control study in Croatian population</atitle><jtitle>Neuropeptides (Edinburgh)</jtitle><addtitle>Neuropeptides</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>47</volume><issue>5</issue><spage>315</spage><epage>319</epage><pages>315-319</pages><issn>0143-4179</issn><eissn>1532-2785</eissn><abstract>Abstract Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu ( OPRM1 ) and kappa ( OPRK1 ) opioid receptors and precursors of their ligands – proopiomelanocortin ( POMC ), coding for beta-endorphin and prodynorphin ( PDYN ) coding for dynorphins, were analyzed in a case–control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger’s criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. 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| ispartof | Neuropeptides (Edinburgh), 2013-10, Vol.47 (5), p.315-319 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adolescent Adult Advanced Basic Science Aged Alcohol dependence Alcoholism Alcoholism - genetics Case-Control Studies Cloninger typology Croatia Endocrinology & Metabolism Enkephalins - genetics Genetic Association Studies Humans Male Middle Aged OPRK1 OPRM1 PDYN Polymorphism, Single Nucleotide POMC Pro-Opiomelanocortin - genetics Protein Precursors - genetics Receptors, Opioid, kappa - genetics Receptors, Opioid, mu - genetics Single nucleotide polymorphism Young Adult |
| title | Opioid system genes in alcoholism: A case–control study in Croatian population |
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