Outer membrane vesicles derived from Bordetella parapertussis as an acellular vaccine against Bordetella parapertussis and Bordetella pertussis infection

Highlights • We measured the protective capacities of OMVs derived from B. parapertussis (OMVsBpp). • We examined the cross protective capacities of OMVsBpp. • Cross protection against B. pertussis was observed. • Commercial aP vaccines offer little protection against B. parapertussis. • Vaccines co...

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Bibliographic Details
Published in:Vaccine 2013-10, Vol.31 (45), p.5262-5268
Main Authors: Bottero, D, Gaillard, M.E, Errea, A, Moreno, G, Zurita, E, Pianciola, L, Rumbo, M, Hozbor, D
Format: Article
Language:English
Subjects:
Acellular vaccine
Allergy and Immunology
Animals
antigens
Applied microbiology
Bacterial diseases
Bacterial Proteins - analysis
Bacteriology
Biological and medical sciences
Bordetella Infections - immunology
Bordetella Infections - prevention & control
Bordetella parapertussis
Bordetella parapertussis - immunology
Bordetella pertussis
Bordetella pertussis - immunology
Disease Models, Animal
Ent and stomatologic bacterial diseases
Exosomes - chemistry
Exosomes - immunology
Female
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Immunization
Infections
Infectious diseases
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
OMVs
Pathogens
Pertussis Vaccine - administration & dosage
Pertussis Vaccine - immunology
Pertussis Vaccine - isolation & purification
Protection
Proteome - analysis
proteomics
Teenagers
Vaccines
Vaccines, Acellular - administration & dosage
Vaccines, Acellular - immunology
Vaccines, Acellular - isolation & purification
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Whooping cough
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Summary:Highlights • We measured the protective capacities of OMVs derived from B. parapertussis (OMVsBpp). • We examined the cross protective capacities of OMVsBpp. • Cross protection against B. pertussis was observed. • Commercial aP vaccines offer little protection against B. parapertussis. • Vaccines containing OMVsBpp are safety.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.08.059