Role of Intravenous Levetiracetam for Acute Seizure Management in Preterm Neonates

Abstract Background Neonatal seizures are common in the first month of life and may impair neurodevelopmental outcome. Current antiepileptic drugs used in the treatment of neonatal seizures have limited efficacy and undesirable side effects. Intravenous levetiracetam is increasingly being used in th...

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Bibliographic Details
Published in:Pediatric neurology 2013-11, Vol.49 (5), p.340-343
Main Authors: Khan, Owais, MD, MPH, Cipriani, Cheryl, MD, Wright, Chanin, PharmD, Crisp, Edwin, MD, Kirmani, Batool, MD
Format: Article
Language:English
Subjects:
Acute Disease
Anticonvulsants - administration & dosage
Electroencephalography
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Injections, Intravenous
levetiracetam
Male
neonatal
neonates
Neurology
Pediatrics
Piracetam - administration & dosage
Piracetam - analogs & derivatives
preterm
Retrospective Studies
seizure management
seizures
Seizures - classification
Seizures - drug therapy
Seizures - etiology
treatment
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Summary:Abstract Background Neonatal seizures are common in the first month of life and may impair neurodevelopmental outcome. Current antiepileptic drugs used in the treatment of neonatal seizures have limited efficacy and undesirable side effects. Intravenous levetiracetam is increasingly being used in the neonatal period to treat seizures. Presently, insufficient data about the efficacy and safety of intravenous levetiracetam in preterm neonates exist. Methods We retrospectively analyzed data from preterm neonates who were treated with intravenous levetiracetam at our institution between January 2007 and December 2011. Data were acquired from review of our institution's electronic medical record regarding patients who were treated with intravenous levetiracetam during the neonatal period (0 to 28 days) and were born at preterm gestation (
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2013.05.008