Intracellular infections in Drosophila melanogaster: host defense and mechanisms of pathogenesis

The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved im...

Full description

Saved in:
Bibliographic Details
Published in:Developmental and comparative immunology 2014-01, Vol.42 (1), p.57-66
Main Authors: Péan, Claire B, Dionne, Marc S
Format: Article
Language:English
Subjects:
Animals
Arthropoda
Bacterial Infections - immunology
Bacterial Infections - microbiology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Drosophila melanogaster
Drosophila melanogaster - immunology
Drosophila Proteins - immunology
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Innate
Intracellular Space
Phagocytosis - immunology
Receptors, Pattern Recognition - immunology
Signal Transduction - immunology
Virulence Factors - genetics
Virulence Factors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2013.04.013