Peripheral blood natural killer cells activation status determined by CD69 upregulation predicts implantation outcome in IVF

Abstract Problem NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. Methods of study Recently, we showed that the proportion of NK that expressed CD69+ after incubation with K562 (CD69stim ) cells reflected the NK population excitation pot...

Full description

Saved in:
Bibliographic Details
Published in:Immunobiology (1979) 2014-03, Vol.219 (3), p.167-171
Main Authors: Dons’koi, Boris V, Chernyshov, Viktor P, Sirenko, Vera Y, Strelko, Galina V, Osypchuk, Dariia V
Format: Article
Language:English
Subjects:
Advanced Basic Science
Allergy and Immunology
Antigens, CD - metabolism
Antigens, Differentiation, T-Lymphocyte - metabolism
Blood Cells - immunology
CD69 expression
Embryo implantation
Embryo Implantation - immunology
Female
Fertilization in Vitro
Humans
Infertility - diagnosis
Infertility - therapy
K562 Cells
Killer Cells, Natural - immunology
Lectins, C-Type - metabolism
Lymphocyte Activation
Natural killer lymphocytes
NK activity
NK stimulation
Pregnancy - immunology
Pregnancy Outcome
Treatment Failure
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Problem NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. Methods of study Recently, we showed that the proportion of NK that expressed CD69+ after incubation with K562 (CD69stim ) cells reflected the NK population excitation potential. In the present study, we investigate the significance of NK activation levels in predicting embryo implantation. Results A qualitative analysis of values distribution in two groups showed that 25/33 (75.8%) women who became pregnant had CD69stim levels that were >30 but
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2013.09.002