The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

• Published in: Medical engineering & physics 2014-02, Vol.36 (2), p.226-232
• Main Authors: Burgin, L.V, Edelsten, L, Aspden, R.M
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Articular cartilage; Biomechanical Phenomena; Cartilage, Articular - metabolism; Cartilage, Articular - physiology; Collagen - metabolism; Composition; Female; Femoral head; Femur; Glycosaminoglycans - metabolism; Human; Humans; Impact; Male; Material properties; Materials Testing; Mechanical properties; Middle Aged; Radiology; Stress, Mechanical; Water - metabolism; Weight-Bearing
• ISSN: 1350-4533; 1873-4030
• DOI: 10.1016/j.medengphy.2013.11.002

Abstract The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5 mJ and velocity 1.25 m s−1 . The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves. Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150 MPa. These values compared with 1–3 MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25% of the variance in modulus.