Mixed Bioengineering–Chemical Synthesis Approach for the Efficient Preparation of Δ7-Dafachronic Acid

Combining bioengineering with chemical synthesis has enabled an efficient method for producing Δ7-dafachronic acid, a steroidal hormone associated with nematode germline longevity. Saccharomyces cerevisiae was engineered to produce 7,24-cholestadienol, a convenient starting material for a four-step...

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Bibliographic Details
Published in:Organic letters 2014-04, Vol.16 (8), p.2188-2191
Main Authors: Kinzurik, Matias I, Hristov, Lachezar V, Matsuda, Seiichi P. T, Ball, Zachary T
Format: Article
Language:English
Subjects:
Animals
Bioengineering
Cholestenes - chemical synthesis
Cholestenes - chemistry
Genes, Helminth - physiology
Germ Cells - metabolism
Longevity - physiology
Molecular Structure
Nematoda - physiology
Saccharomyces cerevisiae - genetics
Steroids
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Summary:Combining bioengineering with chemical synthesis has enabled an efficient method for producing Δ7-dafachronic acid, a steroidal hormone associated with nematode germline longevity. Saccharomyces cerevisiae was engineered to produce 7,24-cholestadienol, a convenient starting material for a four-step synthesis of Δ7-dafachronic acid.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol5006642