Influence of APOE Status on Lexical–Semantic Skills in Mild Cognitive Impairment

This study characterized the relationship between apolipoprotein E (APOE) status and residual semantic abilities in amnestic mild cognitive impairment (MCI). APOE status (ε4 carrier/non ε4 carrier) was determined in 30 amnestic MCIs and in 22 healthy matched non ε4 carrier controls. The lexical char...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2011-05, Vol.17 (3), p.423-430
Main Authors: Biundo, Roberta, Gardini, Simona, Caffarra, Paolo, Concari, Letizia, Martorana, Davide, Neri, Tauro Maria, Shanks, Michael F., Venneri, Annalena
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - genetics
Apolipoproteins E - genetics
Brain
Case-Control Studies
Cognition & reasoning
Cognitive Dysfunction - genetics
Cognitive Dysfunction - physiopathology
Dementia
Disease Progression
Female
Follow-Up Studies
Humans
Linguistics
Male
Medical imaging
Middle Aged
Mutation
Neuropsychological Tests
Radionuclide Imaging
Recognition (Psychology)
Semantics
Studies
Verbal Learning
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Summary:This study characterized the relationship between apolipoprotein E (APOE) status and residual semantic abilities in amnestic mild cognitive impairment (MCI). APOE status (ε4 carrier/non ε4 carrier) was determined in 30 amnestic MCIs and in 22 healthy matched non ε4 carrier controls. The lexical characteristics (age of acquisition, typicality, familiarity) of words produced in a category fluency task were determined. MCIs produced fewer words than controls and these were also earlier acquired and more familiar. The words produced by MCI ε4 carriers were earlier acquired than those of non ε4 carriers. Analyses limited to the first 10 words produced by patients and controls showed similar findings and also revealed that MCI subgroups retrieved first more typical words than controls. Follow up showed higher conversion to Alzheimer's disease (AD) in MCI ε4 carriers than in non ε4 carriers. These findings show that a significant proportion of phenotype variability in performance on category fluency in people at increased AD risk is influenced by genetic factors. These findings explain why category fluency deficits, together with episodic memory deficits, are the only consistent early deficits in MCI patients who convert to AD. (JINS, 2011, 17, 423–430)
ISSN:1355-6177
1469-7661
DOI:10.1017/S135561771100021X