Tetranuclear Gadolinium(III) Porphyrin Complex as a Theranostic Agent for Multimodal Imaging and Photodynamic Therapy

We describe herein the elaborate design of a Gd­(III)–porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM–1 s–1) with 107% increase upon binding to HSA (human serum albumin) (29.2 mM–1 s–1) together with eff...

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Bibliographic Details
Published in:Inorganic chemistry 2014-04, Vol.53 (8), p.4184-4191
Main Authors: Luo, Jian, Chen, Li-Feng, Hu, Ping, Chen, Zhong-Ning
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Contrast Media - chemical synthesis
Contrast Media - chemistry
Gadolinium - chemistry
Humans
Magnetic Resonance Imaging
Metalloporphyrins - chemical synthesis
Metalloporphyrins - chemistry
Microscopy, Confocal
Microscopy, Fluorescence
Molecular Structure
Multimodal Imaging
Optical Imaging
Photochemotherapy
Serum Albumin - chemistry
Singlet Oxygen - analysis
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Summary:We describe herein the elaborate design of a Gd­(III)–porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM–1 s–1) with 107% increase upon binding to HSA (human serum albumin) (29.2 mM–1 s–1) together with efficiently generating singlet oxygen upon exposure to far-red light irradiation at 650 ± 20 nm demonstrate that this Gd­(III)–porphyrin complex with four Gd­(III)–DTTA units bound to tetraphenylporphyrin acts as a potentially theranostic agent with excellent performance for magnetic resonance imaging, optical imaging, and photodynamic therapy.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic500238s