Hyper-IgD and periodic fever syndrome: a new MVK mutation (p.R277G) associated with a severe phenotype

• Published in: Gene 2014-06, Vol.542 (2), p.217-220
• Main Authors: Santos, Joana A., Aróstegui, Juan I., Brito, Maria J., Neves, Conceição, Conde, Marta
• Format: Article
• Language: English
• Subjects: Acute-Phase Reaction - genetics; Anakinra; Child, Preschool; Fever - drug therapy; Fever - genetics; Homozygote; Humans; Hyperimmunoglobulinemia D and periodic fever syndrome; Immunoglobulin D - blood; Immunoglobulin D - genetics; Interleukin 1 Receptor Antagonist Protein - therapeutic use; Male; Mevalonate kinase; Mevalonate Kinase Deficiency - blood; Mevalonate Kinase Deficiency - genetics; Mutation, Missense; New mutation; Phenotype; Phosphotransferases (Alcohol Group Acceptor) - genetics
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2014.03.031

Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS; MIM# 260920) is a rare recessively-inherited autoinflammatory condition caused by mutations in the MVK gene, which encodes for mevalonate kinase, an essential enzyme in the isoprenoid pathway. HIDS is clinically characterized by recurrent episodes of fever and inflammation. Here we report on the case of a 2year-old Portuguese boy with recurrent episodes of fever, malaise, massive cervical lymphadenopathy and hepatosplenomegaly since the age of 12months. Rash, arthralgia, abdominal pain and diarrhea were also seen occasionally. During attacks a vigorous acute-phase response was detected, including elevated erythrocyte sedimentation rate, C-reactive protein, serum amyloid A and leukocytosis. Clinical and laboratory improvement was seen between attacks. Despite normal serum IgD level, HIDS was clinically suspected. Mutational MVK analysis revealed the homozygous genotype with the novel p.Arg277Gly (p.R277G) mutation, while the healthy non-consanguineous parents were heterozygous. Short nonsteroidal anti-inflammatory drugs and corticosteroid courses were given during attacks with poor benefits, whereas anakinra showed positive responses only at high doses. The p.R277G mutation here described is a novel missense MVK mutation, and it has been detected in this case with a severe HIDS phenotype. Further studies are needed to evaluate a co-relation genotype, enzyme activity and phenotype, and to define the best therapeutic strategies. •Normal serum IgD does not exclude HIDS' diagnosis.•Upon HIDS high clinical suspicion, the whole MVK gene should be studied.•In severe disease higher doses of IL-1 antagonist anakinra may be necessary.•Studies are needed to evaluate a relation MVK genotype and disease phenotype.