Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat

Highlights • Maternal separated (MS) animals have increased c-fos expression after CRD compared to NS rats in corticoamygdalar areas. • Increased c-fos expression is also found when the MS CRD group is compared to controls for the same brain areas. • Decreased locomotion in MS rats is not associated...

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Bibliographic Details
Published in:Neuroscience 2014-05, Vol.267, p.252-262
Main Authors: Felice, V.D, Gibney, S.M, Gosselin, R.D, Dinan, T.G, O’Mahony, S.M, Cryan, J.F
Format: Article
Language:English
Subjects:
Amygdala - physiopathology
Analysis of Variance
Animals
Animals, Newborn
Biological and medical sciences
c-fos
Colon - physiopathology
colorectal distension
corticoamygdalar system
Disease Models, Animal
Exploratory Behavior - physiology
Female
Fundamental and applied biological sciences. Psychology
Male
Maternal Deprivation
maternal separation
Neurology
neuronal activation
Prefrontal Cortex - physiopathology
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rats, Sprague-Dawley
Statistics, Nonparametric
stress
Stress, Psychological - pathology
Vertebrates: nervous system and sense organs
Visceral Pain - pathology
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Summary:Highlights • Maternal separated (MS) animals have increased c-fos expression after CRD compared to NS rats in corticoamygdalar areas. • Increased c-fos expression is also found when the MS CRD group is compared to controls for the same brain areas. • Decreased locomotion in MS rats is not associated with differential brain activation in the areas analyzed.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.01.064