Thrombocytopenia: an update

Summary Thrombocytopenia is a common clinical problem with numerous potential causes including decreased bone marrow platelet production, increased peripheral platelet destruction, increased splenic sequestration, and dilution. Investigation of the etiology of thrombocytopenia requires careful consi...

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Bibliographic Details
Published in:International journal of laboratory hematology 2014-06, Vol.36 (3), p.269-278
Main Authors: Smock, K. J., Perkins, S. L.
Format: Article
Language:English
Subjects:
Blood Platelets - metabolism
Bone Marrow - metabolism
Bone Marrow - pathology
Congenital thrombocytopenia
Humans
immune-mediated thrombocytopenia
laboratory testing
microangiopathic hemolytic anemia
Platelet Count
Thrombocytopenia - diagnosis
Thrombocytopenia - etiology
thrombopoiesis
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Summary:Summary Thrombocytopenia is a common clinical problem with numerous potential causes including decreased bone marrow platelet production, increased peripheral platelet destruction, increased splenic sequestration, and dilution. Investigation of the etiology of thrombocytopenia requires careful consideration of clinical history and laboratory features. A complete blood count and peripheral smear review are essential components of the diagnostic work‐up, and physicians should be knowledgeable about appropriate selection and interpretation of more specialized tests, including bone marrow examination, to assist with diagnosis. This review article aims to summarize and address appropriate work‐up of the major and/or life‐threatening causes of thrombocytopenia and some of the better‐characterized congenital thrombocytopenias.
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.12214