Effect of Oxygen-driven Nebulization at Different Oxygen Flows in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

• Published in: The American journal of the medical sciences 2014-05, Vol.347 (5), p.343-346
• Main Authors: Wu, Wen-wen, BD, Jing, Ma, MD, Lu, Gen-di, MD, Hong, Han-han, BD, Shao, Xiao-ping, BD, Rui, Li, BD
• Format: Article
• Language: English
• Subjects: Acute Disease; Adult; Aged; Aged, 80 and over; Blood gas analysis; Blood Gas Analysis - methods; Chronic obstructive pulmonary disease; Female; Humans; Internal Medicine; Male; Middle Aged; Nebulizers and Vaporizers; Oxygen - administration & dosage; Oxygen - blood; Oxygen flow; Oxygen-driven nebulization; Positive-Pressure Respiration - methods; Pulmonary Disease, Chronic Obstructive - blood; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - therapy; Treatment Outcome
• ISSN: 0002-9629; 1538-2990
• DOI: 10.1097/MAJ.0b013e3182937766

Abstract Objectives The aim of this study was to study the effect of oxygen-driven nebulization (ODN) at different oxygen flows on heart rate, respiratory rate, SpO2 , SaO2 , PaO2 , PaCO2 and pH of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. Methods According to random number table, 9 AECOPD patients were randomly divided into 3 groups, numbered A, B and C and treated with ODN. Oxygen flow of groups A, B and C was 4-5, 6-7 and 8-9 L/min, respectively. Heart rate, respiratory rate, SpO2 , SaO2 , PaO2 , PaCO2 and pH were recorded before ODN and 30 minutes after ODN. Statistical differences of data before or after ODN were analyzed by analysis of variance and F-test, whereas data before and after ODN were tested by paired t test. Results There was no significant difference of heart rate, respiratory rate, SpO2 , PaO2 , PaCO2 , SaO2 and pH among 3 groups before ODN or after ODN. The heart rate was increased in all groups after ODN. But significant increase was only present in groups A and C but not in group B. SaO2 was significantly increased in group C after ODN but no statistical difference was observed between before and after ODN in groups A and B. There was no significant change in respiratory rate, SpO2 , PaO2 , PaCO2 , SaO2 and pH between before and after ODN in all groups. Conclusions Optimal oxygen flow in ODN-treating AECOPD patients may be 6-7 L/min.