Imiquimod is not an effective drug for molluscum contagiosum

At week 18, imiquimod was no more effective than was vehicle-containing cream in clearing molluscum contagiosum (24% vs 26% in one study, 24% vs 28% in the other).2 In 2007, the prescribing information approved by the US Food and Drug Administration (FDA) for imiquimod was updated to incorporate res...

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Bibliographic Details
Published in:The Lancet infectious diseases 2014-05, Vol.14 (5), p.372-373
Main Author: Katz, Kenneth A
Format: Article
Language:English
Subjects:
Drug therapy
Humans
Infectious Disease
Infectious diseases
Molluscum Contagiosum - virology
Molluscum contagiosum virus
Mollusks
Pharmacokinetics
Warts
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Summary:At week 18, imiquimod was no more effective than was vehicle-containing cream in clearing molluscum contagiosum (24% vs 26% in one study, 24% vs 28% in the other).2 In 2007, the prescribing information approved by the US Food and Drug Administration (FDA) for imiquimod was updated to incorporate results from these two trials as well as a companion pharmacokinetic study (1490-IMIQ), including a statement that the studies "failed to demonstrate efficacy", and new safety concerns.2 That Chen and colleagues do not include these data highlights persistent deficiencies in dissemination of data from randomised controlled trials.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(14)70728-5