Anti-inflammatory Labdane Diterpenoids from Lagopsis supina

Ten new labdane diterpenoids, lagopsins A–H (1–3, 5, 7–10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11–15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallo...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2014-04, Vol.77 (4), p.1047-1053
Main Authors: Li, Hui, Li, Man-Man, Su, Xiao-Qin, Sun, Jing, Gu, Yu-Fan, Zeng, Ke-Wu, Zhang, Qian, Zhao, Yun-Fang, Ferreira, Daneel, Zjawiony, Jordan K, Li, Jun, Tu, Peng-Fei
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Crystallography, X-Ray
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Lamiaceae - chemistry
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Mice
Molecular Conformation
Molecular Structure
Nitric Oxide - biosynthesis
Plant Leaves - chemistry
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Summary:Ten new labdane diterpenoids, lagopsins A–H (1–3, 5, 7–10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11–15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 14.9–34.9 μM.
ISSN:0163-3864
1520-6025
DOI:10.1021/np5001329