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Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics
Highlights • Medulloblastomas exhibit frequent somatic alterations affecting chromatin modifiers. • Epigenetic profiling provides accurate molecular subgrouping of medulloblastoma. • Epigenome-wide studies using WGBS & ChIPSeq are now being applied to medulloblastoma. • Epigenetic therapy holds...
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Published in: | Neuroscience 2014-04, Vol.264, p.171-185 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Medulloblastomas exhibit frequent somatic alterations affecting chromatin modifiers. • Epigenetic profiling provides accurate molecular subgrouping of medulloblastoma. • Epigenome-wide studies using WGBS & ChIPSeq are now being applied to medulloblastoma. • Epigenetic therapy holds great promise for the future treatment of medulloblastoma. |
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ISSN: | 0306-4522 1873-7544 |
DOI: | 10.1016/j.neuroscience.2013.07.030 |