Cardiac Lesions in 30 Dogs Naturally Infected With Leishmania infantum chagasi

The hearts of 30 dogs naturally infected with Leishmania infantum chagasi were evaluated histologically and immunohistochemically. Myocardial lesions were detected in all dogs, including lymphoplasmacytic myocarditis (27/30), myonecrosis (24/30), increased interstitial collagen (22/30), lepromatous-...

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Bibliographic Details
Published in:Veterinary pathology 2014-05, Vol.51 (3), p.603-606
Main Authors: Rosa, F. A., Leite, J. H. A. C., Braga, E. T., Moreira, P. R. R., Baltazar, F. H., Biondo, A. W., Padua, P. P. M., Vasconcelos, R. O., Camacho, A. A., Ferreira, W. L., Machado, G. F., Marcondes, M.
Format: Article
Language:English
Subjects:
Animals
Dog Diseases - pathology
Dogs
Heart - parasitology
Histological Techniques - veterinary
Immunohistochemistry - veterinary
Leishmania infantum
Leishmaniasis, Visceral - pathology
Leishmaniasis, Visceral - veterinary
Myocarditis - pathology
Myocarditis - veterinary
Myocardium - pathology
Necrosis - pathology
Necrosis - veterinary
Vasculitis - pathology
Vasculitis - veterinary
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Summary:The hearts of 30 dogs naturally infected with Leishmania infantum chagasi were evaluated histologically and immunohistochemically. Myocardial lesions were detected in all dogs, including lymphoplasmacytic myocarditis (27/30), myonecrosis (24/30), increased interstitial collagen (22/30), lepromatous-type granulomatous myocarditis (7/30), fibrinoid vascular change (3/30), and vasculitis (1/30). The parasite was detected in the hearts of 20 of 30 dogs. The number of parasitized cells correlated with the intensity of the inflammation and with the number of granulomas. The results indicate that cardiac lesions are prevalent in dogs with naturally occurring leishmaniasis even in the absence of clinical signs of cardiac disease.
ISSN:0300-9858
1544-2217
DOI:10.1177/0300985813493914