In vitro study and conformational analysis of 1-N-aminohydroxybutyryl derivatives of aminoglycosides in correlation with their inhibitory potency towards lysosomal phospholipases

Aminoglycosides carrying a 1-N-aminohydroxybutyryl side chain and patterned after dibekacin, tobramycin, and kanamycin B, which all possess five amino groups, have been examined for their ability to bind to negatively charged lipids and inhibit lysosomal phospholipase activity.

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Bibliographic Details
Main Authors: Carlier, M B, Brasseur, R, Ruysschaert, J M, Tulkens, P M
Format: Conference Proceeding
Language:English
Online Access:Get full text
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Summary:Aminoglycosides carrying a 1-N-aminohydroxybutyryl side chain and patterned after dibekacin, tobramycin, and kanamycin B, which all possess five amino groups, have been examined for their ability to bind to negatively charged lipids and inhibit lysosomal phospholipase activity.
ISSN:0340-5761