Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis

CXCL5 is a member of CXC chemokines with neutrophilic chemoattractant and pro-angiogenic properties, which has been implicated in the pathological angiogenesis of rheumatoid arthritis and inflammatory bowel diseases. Since aberrant angiogenesis is also involved in the developmental process of system...

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Bibliographic Details
Published in:Archives of Dermatological Research 2014-05, Vol.306 (4), p.331-338
Main Authors: Ichimura, Yohei, Asano, Yoshihide, Akamata, Kaname, Takahashi, Takehiro, Noda, Shinji, Taniguchi, Takashi, Toyama, Tetsuo, Aozasa, Naohiko, Sumida, Hayakazu, Kuwano, Yoshihiro, Yanaba, Koichi, Tada, Yayoi, Sugaya, Makoto, Sato, Shinichi, Kadono, Takafumi
Format: Article
Language:English
Subjects:
Aged
Animals
Cells, Cultured
Chemokine CXCL5 - biosynthesis
Chemokine CXCL5 - blood
Chemokine CXCL5 - genetics
Dermatology
Endothelial Cells - metabolism
Female
Genetic Predisposition to Disease
Humans
Male
Medicine
Medicine & Public Health
Mice
Mice, Knockout
Middle Aged
Original Paper
Promoter Regions, Genetic
Proto-Oncogene Protein c-fli-1 - deficiency
Proto-Oncogene Protein c-fli-1 - genetics
RNA Interference
RNA, Messenger - biosynthesis
RNA, Small Interfering
Scleroderma, Diffuse - blood
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Summary:CXCL5 is a member of CXC chemokines with neutrophilic chemoattractant and pro-angiogenic properties, which has been implicated in the pathological angiogenesis of rheumatoid arthritis and inflammatory bowel diseases. Since aberrant angiogenesis is also involved in the developmental process of systemic sclerosis (SSc), we herein measured serum CXCL5 levels in 63 SSc and 18 healthy subjects and investigated their clinical significance and the mechanism explaining altered expression of CXCL5 in SSc. Serum CXCL5 levels were significantly lower in SSc patients than in healthy subjects. In diffuse cutaneous SSc (dcSSc), serum CXCL5 levels were uniformly decreased in early stage (
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-013-1431-9