Small Cell Tumors of the Thyroid Gland: A Review

The small cell group of thyroid tumors that includes lymphoma, poorly differentiated carcinoma, medullary carcinoma, secondary neoplasms, as well as tumors with uncertain histogenesis, remains as a valid diagnostic cul-de-sac due to its heterogeneous constitution. The existence of small cell thyroid...

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Bibliographic Details
Published in:International Journal of Surgical Pathology 2014-05, Vol.22 (3), p.197-201
Main Authors: Eloy, Catarina, Cameselle-Teijeiro, José Manuel, Rousseau, Emmanuel, Sobrinho-Simões, Manuel
Format: Article
Language:English
Subjects:
Carcinoma, Small Cell
Humans
Thyroid Neoplasms
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Summary:The small cell group of thyroid tumors that includes lymphoma, poorly differentiated carcinoma, medullary carcinoma, secondary neoplasms, as well as tumors with uncertain histogenesis, remains as a valid diagnostic cul-de-sac due to its heterogeneous constitution. The existence of small cell thyroid tumors with EWSR1-FLI1 rearrangement together with neuroendocrine and/or carcinomatous differentiation raises not only differential diagnostic problems but also a very interesting therapeutic dilemma. This review explores the classification of small cell tumors of the thyroid taking into account the immunophenotype and molecular profile of such tumors.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896913510029