Management of Borderline Resectable Pancreatic Cancer

Borderline resectable pancreatic cancers are those that, although technically resectable, are at high risk for margin-positive resection following surgery de novo. Generally, such cancers are characterized by localized primary tumors that involve the mesenteric vasculature to a limited degree and th...

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Bibliographic Details
Published in:Seminars in radiation oncology 2014-04, Vol.24 (2), p.105-112
Main Authors: Katz, Matthew H.G., MD, Crane, Christopher H., MD, Varadhachary, Gauri, MD
Format: Article
Language:English
Subjects:
Combined Modality Therapy
Hematology, Oncology and Palliative Medicine
Humans
Pancreas - diagnostic imaging
Pancreas - surgery
Pancreatectomy - methods
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - surgery
Radiology
Tomography, X-Ray Computed - methods
Ultrasonography
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Summary:Borderline resectable pancreatic cancers are those that, although technically resectable, are at high risk for margin-positive resection following surgery de novo. Generally, such cancers are characterized by localized primary tumors that involve the mesenteric vasculature to a limited degree and that may require venous or hepatic arterial resection at pancreatectomy. In this article, we review diagnosis and staging algorithms, pretreatment strategies, and multidisciplinary treatment protocols for patients with this stage of disease. The rationale for and results following treatment with neoadjuvant chemotherapy and chemoradiation and subsequent surgical resection of the primary tumor are described in detail and existing data are reviewed.
ISSN:1053-4296
1532-9461
DOI:10.1016/j.semradonc.2013.11.006