Effects of three intense sweeteners on fat storage in the C. elegans model

•Caenorhabditis elegans is a practical model for studying fat storage and obesity.•Aspartame reduces fat storage and increases a surrogate marker of lifespan.•AceK increases fat deposition in the presence of insulin resistance.•Aspartame may be the preferred sweetener to promote weight loss. Beverag...

Full description

Saved in:
Bibliographic Details
Published in:Chemico-biological interactions 2014-05, Vol.215, p.1-6
Main Authors: Zheng, Jolene, Greenway, Frank L., Heymsfield, Steven B., Johnson, William D., King, Jason F., King, Michael J., Gao, Chenfei, Chu, Yi-Fang, Finley, John W.
Format: Article
Language:English
Subjects:
Adipose Tissue - cytology
Adipose Tissue - drug effects
Animals
Beverages - analysis
Body Weight - drug effects
Caenorhabditis elegans - cytology
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - genetics
Caenorhabditis elegans - physiology
Insulin sensitivity
Intense sweetener
Intestines - cytology
Intestines - drug effects
Lipids
Longevity - drug effects
Metabolism
Receptor, Insulin - deficiency
Sweetening Agents - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Caenorhabditis elegans is a practical model for studying fat storage and obesity.•Aspartame reduces fat storage and increases a surrogate marker of lifespan.•AceK increases fat deposition in the presence of insulin resistance.•Aspartame may be the preferred sweetener to promote weight loss. Beverages sweetened with caloric sweeteners (CS), glucose, sucrose or high-fructose corn syrup, are associated with weight gain. Beverages sweetened with intense sweeteners (IS) are marketed as low-calorie substitutes to prevent beverages-associated weight gain. Using Caenorhabditis elegans, the effects on intestinal fat deposition (IFD) and pharyngeal pumping rate (PPR) of cola beverages sweetened with glucose, aspartame, or aspartame plus acesulfame-potassium (AceK) were compared. Control groups received Escherichia coli (OP50) only. Study I: the nematodes received additional glucose- or IS-sweetened beverages. Study II: the nematodes received additional glucose, aspartame, or aspartame plus AceK (AAK). Beverages containing CS or IS (aspartame or AAK) did not alter IFD in wild type (N2) or in daf-16 deficiency. The CS cola increased IFD in sir-2.1 deficiency (P
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2014.02.016