Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients

Summary Introduction Studies have indicated that low serum sex hormone‐binding globulin (SHBG) and testosterone levels are associated with nonalcoholic fatty liver disease (NAFLD). However, it remains unclear whether an association exists between SHBG and NAFLD independent of testosterone. Objective...

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Published in:Clinical endocrinology (Oxford) 2014-06, Vol.80 (6), p.877-883
Main Authors: Hua, Xiaomin, Sun, Yanjun, Zhong, Yingjie, Feng, Wenhuan, Huang, Hong, Wang, Weimin, Zhang, Tianyan, Hu, Yun
Format: Article
Language:English
Subjects:
Adult
Aged
Anthropometry
Biological and medical sciences
Blood Glucose - analysis
C-Peptide - chemistry
Case-Control Studies
Diabetes Complications - blood
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty Liver
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Multivariate Analysis
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - diagnosis
Odds Ratio
Other diseases. Semiology
Sex Hormone-Binding Globulin - chemistry
Testosterone - blood
Testosterone - chemistry
Vertebrates: endocrinology
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Summary:Summary Introduction Studies have indicated that low serum sex hormone‐binding globulin (SHBG) and testosterone levels are associated with nonalcoholic fatty liver disease (NAFLD). However, it remains unclear whether an association exists between SHBG and NAFLD independent of testosterone. Objective This study was aimed to investigate the relationship between SHBG and both total and free testosterone levels with NAFLD. Subjects and Measures One hundred and twenty patients with NAFLD and 120 age‐, sex‐ and BMI‐matched patients with non‐NAFLD were enrolled into a case–control study. Serums SHBG, total testosterone (TT), liver enzymes, lipids, insulin, C‐peptide and plasma glucose were measured. Free testosterone (FT) and fatty liver index were calculated. Results Serum SHBG levels were significantly lower in NAFLD group than in non‐NAFLD group (24·5 ± 11·0 vs 37·6 ± 14·4 nm, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12360