Combined Supine and Prone Myocardial Perfusion Single-Photon Emission Computed Tomography With a Cadmium Zinc Telluride Camera for Detection of Coronary Artery Disease

Background: Myocardial perfusion SPECT (MPS) traditionally requires the patient to be in the supine position, but diaphragmatic attenuation of the inferior wall reduces test specificity. The aim of this study was to assess the feasibility of combined MPS in the supine and prone positions using a nov...

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Bibliographic Details
Published in:Circulation Journal 2014, Vol.78(5), pp.1169-1175
Main Authors: Nishiyama, Yoshiko, Miyagawa, Masao, Kawaguchi, Naoto, Nakamura, Masashi, Kido, Tomoyuki, Kurata, Akira, Kido, Teruhito, Ogimoto, Akiyoshi, Higaki, Jitsuo, Mochizuki, Teruhito
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cadmium zinc telluride
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Humans
Middle Aged
Myocardial ischemia
Myocardial Perfusion Imaging - instrumentation
Myocardial Perfusion Imaging - methods
Myocardium
Organophosphorus Compounds - administration & dosage
Organotechnetium Compounds - administration & dosage
Prone imaging
Radiography
Radiopharmaceuticals - administration & dosage
Sensitivity and Specificity
Single-photon emission computed tomography
Technetium Tc 99m Sestamibi - administration & dosage
Tomography, Emission-Computed, Single-Photon - instrumentation
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Background: Myocardial perfusion SPECT (MPS) traditionally requires the patient to be in the supine position, but diaphragmatic attenuation of the inferior wall reduces test specificity. The aim of this study was to assess the feasibility of combined MPS in the supine and prone positions using a novel cadmium zinc telluride (CZT) camera. Methods and Results: A total of 276 consecutive patients with suspected/known coronary artery disease (CAD) who underwent single-day 99mTc-tetrofosmin or 99mTc-sestamibi stress/rest CZT SPECT, were enrolled in the study. Seventy-six underwent coronary angiography. Five-minute scan in the supine (S) position and thereafter in the prone (P) position produced images that were visually interpreted to obtain summed stress (SSS) and rest (SRS) scores. A combined stress score (C-SSS) was calculated by grouping anterior perfusion defects observed during supine imaging with inferior half segments observed during prone imaging. The SSS for the supine, prone, and combined protocols were 9±8, 7±8, and 7±8, respectively (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-13-1316