Mechanisms of Reparative Regeneration of Rat Testis after Injection of Paclitaxel

Population of spermatogonia was reduced in 2, 3, and 6 months after single intravenous injection of antitumor drug paclitaxel in maximum tolerated dose (MTD). The count of Sertoli cell increased in 3 months after the start of the experiment. The maturity of the seminiferous tubule epithelium was low...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-02, Vol.156 (4), p.483-485
Main Authors: Borovskaya, T. G., Shchemerova, Y. A., Poluektova, M. E., Vychuzhanina, A. V., Goldberg, V. E., Kinsht, D. N., Yershov, K. I., Madonov, P. G.
Format: Article
Language:English
Subjects:
Animal experimentation
Animals
Antimitotic agents
Antineoplastic agents
Antineoplastic Agents, Phytogenic - toxicity
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Male
Maximum Tolerated Dose
Paclitaxel - toxicity
Pathology
Rats, Wistar
Regeneration
Seminiferous Tubules - drug effects
Seminiferous Tubules - physiopathology
Sertoli Cells - drug effects
Sertoli Cells - physiology
Spermatogenesis
Spermatogonia - drug effects
Spermatogonia - physiology
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Summary:Population of spermatogonia was reduced in 2, 3, and 6 months after single intravenous injection of antitumor drug paclitaxel in maximum tolerated dose (MTD). The count of Sertoli cell increased in 3 months after the start of the experiment. The maturity of the seminiferous tubule epithelium was lower than in intact rats. Spermatogenesis productivity did not differ from that in intact animals 6 months after start of the experiment. These data indicate that regeneration of the spermatogenous tissue after paclitaxel treatment is realized via renewal of the spermatogenic epithelium, but considering the amount of spermatogonial cell population, the recovery rate would be low.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2380-9