Application of gellan gum in pharmacy and medicine

[Display omitted] Over the past few decades, microbial polysaccharides have been under intense investigation due to their advantageous physicochemical properties. A great structural diversity of these biomolecules has led to multiple applications in food industry, personal care products, pharmacy an...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-05, Vol.466 (1-2), p.328-340
Main Authors: Osmałek, Tomasz, Froelich, Anna, Tasarek, Sylwia
Format: Article
Language:English
Subjects:
Animals
Biomedical Technology
Chemistry, Pharmaceutical
Controlled release
Gellan gum
Humans
Hydrogels
Polysaccharides
Polysaccharides, Bacterial - chemistry
Technology, Pharmaceutical
Tissue engineering
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Summary:[Display omitted] Over the past few decades, microbial polysaccharides have been under intense investigation due to their advantageous physicochemical properties. A great structural diversity of these biomolecules has led to multiple applications in food industry, personal care products, pharmacy and medicine. Currently, one of the most widely studied and fully described member of this group is gellan. It is a linear polymer produced by Sphingomonas elodea. A polymer chain of gellan consists of a tetrasaccharide repeating unit of l-rhamnose, d-glucose and d-glucuronate. So far most of the studies have been focused on the application of gellan as a food ingredient. However, due to the unique structure and beneficial properties, gellan is currently described as a potent multifunctional additive for various pharmaceutical products. Specific gelling properties in different media led to the development of controlled release forms based on gellan. Various formulations have been studied including oral, ophthalmic, nasal and other. Recent reports suggest that gellan-based materials can also be used in regenerative medicine, stomatology or gene transfer technology.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.03.038