In-line implementation of an image-based particle size measurement tool to monitor hot-melt extruded pellets

[Display omitted] •In-line particle size analysis during continuous hot-die face pelletizing.•Particle size measurement via stereo imaging with three different colored LED light sources.•Agreement between in-line and off-line particle size measurements.•In-line information about surface texture and...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-05, Vol.466 (1-2), p.181-189
Main Authors: Treffer, Daniel, Wahl, Patrick R., Hörmann, Theresa R., Markl, Daniel, Schrank, Simone, Jones, Ian, Cruise, Paul, Mürb, Reinhardt-Karsten, Koscher, Gerold, Roblegg, Eva, Khinast, Johannes G.
Format: Article
Language:English
Subjects:
Acetaminophen - chemistry
Drug Compounding - instrumentation
Hot Temperature
Hot-die face pelletizing
Hot-melt extrusion
Image Processing, Computer-Assisted
Light
Measurement position
Online Systems
Particle imaging
Particle Size
Process analytical technology
Stearic Acids - chemistry
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Summary:[Display omitted] •In-line particle size analysis during continuous hot-die face pelletizing.•Particle size measurement via stereo imaging with three different colored LED light sources.•Agreement between in-line and off-line particle size measurements.•In-line information about surface texture and shape. This work focuses on the implementation and application of an in-line particle measurement tool to monitor particle properties of hot-melt extruded pellets. A novel image analysis system (Eyecon) is used to analyze pellets with a size of approximately 1mm. The method is based on photometric stereo imaging, which is achieved by three different-colored light sources arranged circularly around the lens. Several implementations, whereby the product stream was led through the optical sampling volume, have been tested. The advantages and disadvantages of each implementation are discussed and evaluated. The most suitable implementation was applied to an extrusion run with constant throughput and different cutting frequencies resulting in different pellet sizes. A particle size distribution comparison between the image analysis system and an off-line reference particle analysis (QICPIC) showed good agreement although only a small fraction of the particles were analyzed in-line. Additionally, some illustrative examples for process development are given. With this approach the capability of hot-die face pelletizing to manufacture nearly-spherical pellets with a narrow size distribution is proven.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.03.022