Neuropsychological impairments in elderly Neurofibromatosis type 1 patients

Abstract Cognitive performance is compromised in Neurofibromatosis type 1 (NF1) patients, but neuropsychological data including elderly NF1 are extremely sparse. We compared the cognitive performance of a small elderly NF1 group ( n  = 5) with an age-matched healthy control group ( n  = 49). NF1 gro...

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Bibliographic Details
Published in:European journal of medical genetics 2014-04, Vol.57 (5), p.216-219
Main Authors: Costa, Danielle de Souza, de Paula, Jonas Jardim, de Rezende, Nilton Alves, Rodrigues, Luiz Oswaldo Carneiro, Malloy-Diniz, Leandro Fernandes, Romano-Silva, Marco Aurélio, Miranda, Débora Marques de
Format: Article
Language:English
Subjects:
Aged
Aging
Case-Control Studies
Cognition
Elderly
Executive Function
Female
Humans
Male
Medical Education
Memory, Short-Term
Middle Aged
Neurofibromatosis 1 - psychology
Neurofibromatosis type 1
Neuropsychology
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Summary:Abstract Cognitive performance is compromised in Neurofibromatosis type 1 (NF1) patients, but neuropsychological data including elderly NF1 are extremely sparse. We compared the cognitive performance of a small elderly NF1 group ( n  = 5) with an age-matched healthy control group ( n  = 49). NF1 group performed worse than control group on a global cognitive impairment task, verbal working memory, and visuospatial functioning. The results suggest that cognitive impairment is an important feature of NF1 across lifespan, including elderly individuals. Future studies approaching the NF1 cognitive profile might benefit from looking at the mechanisms linked to the age-related aspects of cognitive decline.
ISSN:1769-7212
1878-0849
DOI:10.1016/j.ejmg.2014.02.004