Cross-Physical Dependence of Several Drugs in Methaqualone-Dependent Rats

We investigated the characteristics of physical dependence on methaqualone. Rats were made physically dependent on methaqualone by the use of the drug-admixed food (DAF) method for 33 days. Pentobarbital, barbital, ethanol and diazepam were cross-administered against methaqualone to evaluate the deg...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1988, Vol.46(4), pp.403-410
Main Authors: SUZUKI, Tsutomu, KOIKE, Yoko, CHIDA, Yasuhiro, MISAWA, Miwa
Format: Article
Language:English
Subjects:
Animals
Barbital - adverse effects
Biological and medical sciences
Diazepam - adverse effects
Ethanol - adverse effects
Hypnotics. Sedatives
Male
Medical sciences
Methaqualone - adverse effects
Neuropharmacology
Pentobarbital - adverse effects
Pharmacology. Drug treatments
Postural Balance - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - drug effects
Psychopharmacology
Rats
Rats, Inbred Strains
Substance Withdrawal Syndrome - physiopathology
Substance-Related Disorders - physiopathology
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Summary:We investigated the characteristics of physical dependence on methaqualone. Rats were made physically dependent on methaqualone by the use of the drug-admixed food (DAF) method for 33 days. Pentobarbital, barbital, ethanol and diazepam were cross-administered against methaqualone to evaluate the degree of suppression of methaqualone withdrawal signs as an index for the cross-physical dependence liability of these drugs to methaqualone. To evaluate the cross-physical dependence liability, we used AUC of body weight loss and withdrawal scores between the first cross-administration (9 hr after the withdrawal) and 27 hr after the withdrawal. AUC of weight loss was significantly suppressed by the four test drugs as compared to each control. Withdrawal scores were also significantly inhibited by the cross-administration of barbital, ethanol and diazepam. Considering that the rats given barbital or ethanol fell asleep after the cross-administration, diazepam seems to cause the strongest suppression of methaqualone withdrawal signs among the four test drugs. Thus, physical dependence on methaqualone may be similar by nature to that on benzodiazepines rather than barbiturates and alcohol.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.46.403