Innate immune cells in inflammation and cancer

The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate n...

Full description

Saved in:
Bibliographic Details
Published in:Cancer immunology research 2013-08, Vol.1 (2), p.77-84
Main Authors: Nowarski, Roni, Gagliani, Nicola, Huber, Samuel, Flavell, Richard A
Format: Article
Language:English
Subjects:
Dendritic Cells - immunology
Humans
Immunity, Innate - immunology
Inflammation - immunology
Macrophages - immunology
Monocytes - immunology
Neoplasms - immunology
Neutrophils - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.
ISSN:2326-6066
2326-6074
DOI:10.1158/2326-6066.CIR-13-0081