Multipotent mesenchymal stromal cells in otorhinolaryngology

Abstract Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative med...

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Bibliographic Details
Published in:Medical hypotheses 2014-06, Vol.82 (6), p.769-773
Main Authors: Skoloudik, Lukas, Chrobok, Viktor, Kalfert, David, Koci, Zuzana, Filip, Stanislav
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - cytology
Bone and Bones - physiology
Cartilage - cytology
Cartilage - physiology
Cell Differentiation - physiology
Guided Tissue Regeneration - methods
Humans
Internal Medicine
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stromal Cells - physiology
Models, Biological
Nerve Tissue - cytology
Nerve Tissue - physiology
Otolaryngology - methods
Regenerative Medicine - methods
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Summary:Abstract Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2014.03.022