Biomimetic PEG-catecholates for stabile antifouling coatings on metal surfaces: applications on TiO2 and stainless steel

Trimeric catecholates have been designed for the stable immobilization of effector molecules on metal surfaces. The design of these catecholates followed a biomimetic approach and was inspired by natural multivalent metal binders, such as mussel adhesion proteins (MAPs) and siderophores. Three catec...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-05, Vol.117, p.185-192
Main Authors: Khalil, Faiza, Franzmann, Elisa, Ramcke, Julian, Dakischew, Olga, Lips, Katrin S, Reinhardt, Alexander, Heisig, Peter, Maison, Wolfgang
Format: Article
Language:English
Subjects:
Aged
Biofouling - prevention & control
Biological Assay
Biomimetic Materials - chemistry
Biomimetic Materials - pharmacology
Catechols - chemistry
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Humans
Male
Metals - pharmacology
Middle Aged
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Stainless Steel - pharmacology
Surface Properties
Titanium - pharmacology
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Summary:Trimeric catecholates have been designed for the stable immobilization of effector molecules on metal surfaces. The design of these catecholates followed a biomimetic approach and was inspired by natural multivalent metal binders, such as mussel adhesion proteins (MAPs) and siderophores. Three catecholates have been conjugated to central scaffolds based on adamantyl or trisalkylmethyl core structures. The resulting triscatecholates have been immobilized on TiO2 and stainless steel. In a proof of concept study we have demonstrated the high stability of the resulting nanolayers at neutral and slightly acidic pH. Furthermore, polyethylene glycol (PEG) conjugates of our triscatecholates have been synthesized and were immobilized on TiO2 and stainless steel. The PEG coated surfaces showed excellent antifouling properties upon exposure to human blood and bacteria as demonstrated by fluorescence microscopy, ellipsometry and a bacterial assay with Staphylococcus epidermidis. In addition, our PEG-triscatecholates showed no cytotoxicity against bone-marrow stem cells on TiO2.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2014.02.022