Paracetamol (acetaminophen): a blessing or a hidden curse?

This Journal has recently published a splendid review of all you need to know about paracetamol (Graham et al. 2013 ), an analgesic widely used in the long-term management of arthritis. It clearly presents the science and hard facts. This commentary, by contrast, discusses some aspects of the metaph...

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Bibliographic Details
Published in:Inflammopharmacology 2014-02, Vol.22 (1), p.63-65
Main Authors: Whitehouse, M. W., Butters, D. E.
Format: Article
Language:English
Subjects:
Acetaminophen - pharmacology
Acetaminophen - therapeutic use
Allergology
Analgesics, Non-Narcotic - pharmacology
Analgesics, Non-Narcotic - therapeutic use
Animals
Biomedical and Life Sciences
Biomedicine
Dermatology
Gastroenterology
Humans
Immunology
Inflammation - drug therapy
Pharmacology/Toxicology
Points of View
Rheumatology
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Summary:This Journal has recently published a splendid review of all you need to know about paracetamol (Graham et al. 2013 ), an analgesic widely used in the long-term management of arthritis. It clearly presents the science and hard facts. This commentary, by contrast, discusses some aspects of the metapharmacology of paracetamol; particularly by asking questions of how we might extract more benefit and suffer less adverse reactions when using this analgesic in the context of non-transient inflammation. As both a drug and a toxin, paracetamol exemplifies how beneficial and/or deleterious responses may be conditioned by circumstances (disease stress, nutritional status, fasting, etc.).
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-013-0189-1