Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer

Abstract Combining oncolytic viruses with conventional therapy such as radiation is an innovative option for pancreatic cancer. We demonstrated that combination of GLV-1h151 and radiation yielded a synergistic cytotoxic effect, with the greatest effect achieved in the AsPC-1cell line. Combination tr...

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Bibliographic Details
Published in:Cancer letters 2014-03, Vol.344 (2), p.282-290
Main Authors: Dai, M.H, Liu, S.L, Chen, N.G, Zhang, T.P, You, L, Q. Zhang, F, Chou, T.C, Szalay, A.A, Fong, Y, Zhao, Y.P
Format: Article
Language:English
Subjects:
Adenocarcinoma - radiotherapy
Adenocarcinoma - therapy
Adenocarcinoma - virology
Animals
Cancer therapies
Cell Line, Tumor
Chemotherapy
Combined Modality Therapy
Cytotoxicity
Gene expression
Hematology, Oncology and Palliative Medicine
Humans
Infections
Kinases
Mice
Mice, Inbred BALB C
Oncolytic Virotherapy - methods
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - radiotherapy
Pancreatic Neoplasms - therapy
Pancreatic Neoplasms - virology
Radiation therapy
Random Allocation
Synergism
Vaccinia virus
Vaccinia virus - physiology
Virus
Viruses
Xenograft Model Antitumor Assays
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Summary:Abstract Combining oncolytic viruses with conventional therapy such as radiation is an innovative option for pancreatic cancer. We demonstrated that combination of GLV-1h151 and radiation yielded a synergistic cytotoxic effect, with the greatest effect achieved in the AsPC-1cell line. Combination treatment significantly increased apoptosis compared with either single treatment or the control group. In mice bearing human pancreatic tumor xenografts, combination treatment resulted in significantly enhanced inhibition of tumor growth. No evidence of toxicity was observed in mice. These results indicate that the combination of GLV-1h151 and radiation has great potential for translation into clinic practice.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.11.007