Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: The first consensus meeting in Kofu 2013

From a clinicopathological conference on nine elderly patients with Epstein–Barr virus (EBV)‐associated T/natural killer (NK)‐cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these el...

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Bibliographic Details
Published in:Journal of dermatology 2014-01, Vol.41 (1), p.40-42
Main Authors: Hamada, Toshihisa, Nakamura, Shigeo, Ko, Young-Hyeh, Yoshino, Tadashi, Ohshima, Koichi, Matsuzawa, Takamitsu, Miura, Keiko, Takahashi, Toshifumi, Nomura, Hisashi, Hoshino, Tomomi, Suzuki, Daisuke, Shimada, Shinji, Iwatsuki, Keiji
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
centroblastoid
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - pathology
Humans
hydroa vacciniforme
Lymphoma - pathology
Lymphoma - virology
nasal type
Skin - pathology
T/natural killer-cell lymphoma
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Summary:From a clinicopathological conference on nine elderly patients with Epstein–Barr virus (EBV)‐associated T/natural killer (NK)‐cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T‐cell lymphoma, nasal type (ENKL) with an NK‐cell phenotype, and two patients had EBV+ T‐cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV‐related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV+CD8+CD56+/− lymphocytes may be responsible for the development of PLEVA or HV‐like cutaneous lesions in the elderly.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.12373