Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Schistosomiasis is caused by Schistosoma mansoni and is a public health problem in Brazil. The typical granulomatous lesion is associated with the increase in the oxidative damage by generation of free radicals. The aim of this work was to correlate some oxidative stress markers with the worm burden...

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Bibliographic Details
Published in:Acta parasitologica 2012-06, Vol.57 (2), p.160-166
Main Authors: Cunha, G. M. M., Silva, V. M. A., Bessa, K. D. G., Bitencourt, M. A. O., Macêdo, U. B. O., Freire-Neto, F. P., Martins, R. R., Assis, C. F., Lemos, T. M. A. M., Almeida, M. G., Freire, A. C. G.
Format: Article
Language:English
Subjects:
Animal Systematics/Taxonomy/Biogeography
Animals
Antioxidants - metabolism
Biomarkers
Biomedical and Life Sciences
Biomedicine
Ecology
Free radicals
Humans
Liver - parasitology
Liver - physiology
Medical Microbiology
Microbiology
Original Paper
Oxidants - metabolism
Oxidative stress
Oxidative Stress - physiology
Parasitology
Schistosoma mansoni
Schistosoma mansoni - physiology
Schistosomiasis mansoni - metabolism
Schistosomiasis mansoni - parasitology
Schistosomiasis mansoni - pathology
worm burden
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Summary:Schistosomiasis is caused by Schistosoma mansoni and is a public health problem in Brazil. The typical granulomatous lesion is associated with the increase in the oxidative damage by generation of free radicals. The aim of this work was to correlate some oxidative stress markers with the worm burden on carriers of schistosomiasis (n = 30) in the acute phase in comparison to healthy subjects (n = 30). The pro-oxidant parameter used was the colorimetric quantification of reactive substances to thiobarbituric acid, while the antioxidant markers used were blood content of reduced glutathione and determination of the activity of catalase. The worm burden was assessed by Kato-Katz method. The results pointed out that initially there was no difference in the catalase activity. However, there was a positive correlation between the increase in parasitic load and intensity of lipid peroxidation, and decrease in the content of reduced glutathione. Additionally, only the aspartate aminotransferase levels presented to be high, while there was a decrease in bilirubin level. Therefore, a possible association between the establishment of the oxidative stress in tissue and the parasitic load of Schistosoma mansoni is suggested.
ISSN:1230-2821
1896-1851
DOI:10.2478/s11686-012-0026-5