EFFECTS OF 17[beta]-ESTRADIOL ON THE ACUTE NECROTIZING PANCREATITIS AFTER ONSET IN RATS

• Published in: European journal of inflammation 2013-12, Vol.11 (3), p.675-683
• Main Authors: Alhan, E, Cinel, A, Turkyilmaz, S, Ercin, C, Kural, B V, Usta, A
• Format: Article
• Language: English
• ISSN: 1721-727X

The aim of this study was to investigate the influence of 17[beta]-estradiol (E sub(2)) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. Rats were divided into six groups as sham + saline, sham + single dose E sub(2) (SDE sub(2)), sham + multiple dose E sub(2) (MDE sub(2)), ANP + saline, ANP + SDE sub(2), and ANP + MDE sub(2). ANP in rats was induced by glycodeoxycholic acid. The extent of acinar cell injury, mortality, systemic cardiorespiratory variables, functional capillary density (FCD), renal/hepatic functions, and changes in some enzyme markers for pancreatic and lung tissue were investigated during ANP in rats. The induction of ANP resulted in a significant increase in the mortality rate, pancreatic necrosis, and serum activity of amylase, alanine aminotransferase (ALT), interleukin (IL)-6, lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, and tissue activity of myeloperoxidase (MPO) and malondialdehyde (MDA) in the pancreas and lung, and a significant decrease in concentrations of calcium, blood pressure, urine output, p0 sub(2), and functional capillary density (FCD). The use of E sub(2) did not alter these changes. E sub(2) demonstrated no effect on the course of ANP in rats. Therefore, it has no value in the treatment during acute pancreatitis.