Roseola infantum and its causal human herpesviruses

Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Roseola is caused by...

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Bibliographic Details
Published in:International journal of dermatology 2014-04, Vol.53 (4), p.397-403
Main Authors: Stone, Rivka C., Micali, Giuseppe A., Schwartz, Robert A.
Format: Article
Language:English
Subjects:
Diagnosis, Differential
Exanthema Subitum - virology
Fever - virology
Herpesvirus 6, Human
Herpesvirus 7, Human
Human herpesvirus 6
Humans
Seizures - virology
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Summary:Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Roseola is caused by infection with human herpesviruses 6 or 7 (HHV‐6/7), which are acquired at a young age. Diagnosis is made by serology or by virus detection in body fluids and tissues. Treatment of roseola is supportive; recovery is usually complete with no significant sequelae. However, HHV‐6/7 can reactivate in immunocompetent as well as immunocompromised individuals with severe systemic consequence.
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.12310