Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy

Abstract The purpose of this meta-analysis was to detect the association between the cholesteryl ester transfer protein gene polymorphisms and the risk of Alzheimer's disease (AD), carotid atherosclerosis, longevity, and the efficacy of statin therapy. Databases of MEDLINE, EMBASE, BIOSIS, the...

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Bibliographic Details
Published in:Neurobiology of aging 2014-06, Vol.35 (6), p.1513.e13-1513.e23
Main Authors: Li, Qing, Huang, Ping, He, Qian-Chao, Lin, Quan-Zhen, Wu, Jian, Yin, Rui-Xing
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E4
Asian Continental Ancestry Group
Carotid Artery Diseases - genetics
Carotid atherosclerosis
Cholesterol Ester Transfer Proteins - genetics
Cholesteryl ester transfer protein
Databases, Bibliographic
Efficacy of statin therapy
Female
Genetic Association Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Internal Medicine
Longevity
Longevity - genetics
Male
Meta-analysis
Middle Aged
Neurology
Polymorphism, Genetic - genetics
Polymorphisms
Risk
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Summary:Abstract The purpose of this meta-analysis was to detect the association between the cholesteryl ester transfer protein gene polymorphisms and the risk of Alzheimer's disease (AD), carotid atherosclerosis, longevity, and the efficacy of statin therapy. Databases of MEDLINE, EMBASE, BIOSIS, the Cochrane Library, and the Chinese National Knowledge Infrastructure were systematically searched. Thirty-two studies were included in this meta-analysis. There was no difference in the I405V, C629A, and Taq1B polymorphisms between AD and control groups. However, stratified analysis showed that AD group had higher B2B2 genotype frequency than control group in Asian populations with APOE4+ in Taq1B. I405V and Taq1B polymorphisms were not associated with the risk of carotid atherosclerosis and longevity. The efficacy of statin therapy was not associated with Taq1B polymorphism. In conclusion, there was no association between cholesteryl ester transfer protein gene polymorphisms and the risk of AD, carotid atherosclerosis, longevity, and the efficacy of statin therapy in the pooled effects of overall population. However, the B2B2 genotype of Taq1B was associated with increased risk of AD in the Asian populations with APOE4+.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2013.12.032