Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies

Highlights • Induction of HIV-1 envelope glycoprotein (Env) directed broadly neutralizing antibodies (bNAbs) is a potential vaccine strategy. • Cell-to-cell transmission of HIV-1 at immune cell synapses is a highly efficient method of HIV-1 dissemination. • Infection at synapses is dependent upon re...

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Bibliographic Details
Published in:Vaccine 2013-12, Vol.31 (49), p.5789-5797
Main Authors: Schiffner, Torben, Sattentau, Quentin J, Duncan, Christopher J.A
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Neutralizing - immunology
Antigens
Applied microbiology
Biological and medical sciences
Broadly neutralizing
CD4-binding site
Dendritic cell
Dendritic Cells - immunology
env Gene Products, Human Immunodeficiency Virus - immunology
Envelope
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
HIV
HIV Antibodies - immunology
HIV Infections - immunology
HIV-1 - immunology
HIV-1 - physiology
Human immunodeficiency virus
Human immunodeficiency virus 1
Humans
Immune Evasion
Immunization
Immunological Synapses - virology
Infections
Infectious synapse
Lymphocytes
Macrophage
Microbiology
Miscellaneous
Mutation
T cell
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virological synapse
Virology
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Summary:Highlights • Induction of HIV-1 envelope glycoprotein (Env) directed broadly neutralizing antibodies (bNAbs) is a potential vaccine strategy. • Cell-to-cell transmission of HIV-1 at immune cell synapses is a highly efficient method of HIV-1 dissemination. • Infection at synapses is dependent upon receptor engagement and Env-mediated fusion and thus is amenable to bNAb inhibition. • Epitope-specific reduction in neutralization activity compared to cell-free inhibition has been reported. • The mechanisms governing the relative restriction in neutralization activity in cell-to-cell transmission are unknown.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.10.020