Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids

The performance characteristics of two new plastic membrane ion selective electrodes (ISEs) used for the determination of famciclovir (Fcv) based on the ion associate of Fcv with phosphotungstic acid (PTA) or phosphomolybdic acid (PMA) are described. Different experimental conditions as type of plas...

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Bibliographic Details
Published in:Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2013-02, Vol.89, p.26-33
Main Authors: Rezk, Mohamed S., El Nashar, Rasha M.
Format: Article
Language:English
Subjects:
2-Aminopurine - analogs & derivatives
2-Aminopurine - analysis
2-Aminopurine - blood
2-Aminopurine - chemistry
2-Aminopurine - urine
Blood Chemical Analysis - instrumentation
Blood Chemical Analysis - methods
Dissolution testing
Electrodes
Famciclovir
Flow Injection Analysis
Ion-selective electrodes
Limit of Detection
Membranes, Artificial
Molybdenum - chemistry
Phosphoric Acids - chemistry
Phosphotungstic Acid - chemistry
Polyvinyl Chloride - chemistry
Potentiometry - instrumentation
Potentiometry - methods
Tablets
Temperature
Urinalysis - instrumentation
Urinalysis - methods
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Summary:The performance characteristics of two new plastic membrane ion selective electrodes (ISEs) used for the determination of famciclovir (Fcv) based on the ion associate of Fcv with phosphotungstic acid (PTA) or phosphomolybdic acid (PMA) are described. Different experimental conditions as type of plasticizer to be incorporated in the membrane, life span, effect of soaking, pH, temperature, and interferences were studied. Both electrodes showed similar performance under these conditions, exhibiting Nernstian slopes of S (Fcv-PTA)=58.60±0.84mV/decade and S (Fcv-PMA)=58.77±0.68mV/decade within a usable concentration range of 10−5–10−2 [Fcv/M] at 298/K. Famciclovir was assayed potentiometrically in its pure solution, pharmaceutical preparations and biological fluids (urine and plasma) using proposed electrodes under batch and flow injection analysis (FIA) conditions with a recovery % ranging between 96.76% and 102.83% having RSD of 0.66%–1.81%. The electrodes were also successfully applied in the determination of the dissolution profile of Fcv tablets and the results came in agreement with the validated results of the HPLC method obtained from the quality control unit of the company producing the tablets.
ISSN:1567-5394
1878-562X
DOI:10.1016/j.bioelechem.2012.08.006