Imaging hypothalamic activity using diffusion weighted magnetic resonance imaging in the mouse and human brain

Hypothalamic appetite regulation is a vital homeostatic process underlying global energy balance in animals and humans, its disturbances resulting in feeding disorders with high morbidity and mortality. The objective evaluation of appetite remains difficult, very often restricted to indirect measure...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2013-01, Vol.64, p.448-457
Main Authors: Lizarbe, Blanca, Benítez, Ania, Sánchez-Montañés, Manuel, Lago-Fernández, Luis F., Garcia-Martin, María L., López-Larrubia, Pilar, Cerdán, Sebastián
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Adult
Algorithms
Animals
Appetite - physiology
Appetite regulation
Biexponential diffusion
Biological and medical sciences
Body temperature
Brain Mapping - methods
Cerebral activation
Diet
Diffusion
Diffusion Magnetic Resonance Imaging
Diffusion weighted MRI
Experiments
Fasting - physiology
Food
Functional imaging
Fundamental and applied biological sciences. Psychology
Humans
Hypothalamus - physiology
Image analysis
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Insulin
Male
Methods
Mice
Mice, Inbred C57BL
NMR
Nuclear magnetic resonance
Nutrition research
Reproducibility of Results
Rodents
Sensitivity and Specificity
Species Specificity
Studies
Vertebrates: nervous system and sense organs
Volunteers
Young Adult
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Summary:Hypothalamic appetite regulation is a vital homeostatic process underlying global energy balance in animals and humans, its disturbances resulting in feeding disorders with high morbidity and mortality. The objective evaluation of appetite remains difficult, very often restricted to indirect measurements of food intake and body weight. We report here, the direct, non‐invasive visualization of hypothalamic activation by fasting using diffusion weighted magnetic resonance imaging, in the mouse brain as well as in a preliminary study in the human brain. The brain of fed or fasted mice or humans were imaged at 7 or 1.5Tesla, respectively, by diffusion weighted magnetic resonance imaging using a complete range of b values (10
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2012.09.033