Serum ferritin and paraoxonase-1 in canine leishmaniosis

Abstract Ferritin and paraoxonase-1 (PON-1) were measured in dogs experimentally infected by Leishmania infantum (during experimental infection and following treatment) and also in naturally-infected dogs which presented different degrees of proteinuria. Experimentally-infected dogs were monitored f...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2014-01, Vol.37 (1), p.23-29
Main Authors: Martinez-Subiela, S, Cerón, J.J, Strauss-Ayali, D, Garcia-Martinez, J.D, Tecles, F, Tvarijonaviciute, A, Caldin, M, Baneth, G
Format: Article
Language:English
Subjects:
Allergy and Immunology
Allopurinol - therapeutic use
Animals
Aryldialkylphosphatase - blood
C-Reactive Protein - metabolism
Creatinine - urine
Dog
Dog Diseases - blood
Dog Diseases - drug therapy
Dog Diseases - parasitology
Dog Diseases - urine
Dogs
Enzyme Inhibitors - therapeutic use
Female
Ferritin
Ferritins - blood
Infectious Disease
Leishmania infantum
Leishmania infantum - isolation & purification
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - parasitology
Leishmaniasis, Visceral - urine
Leishmaniasis, Visceral - veterinary
Leishmaniosis
Male
Paraoxonase-1
Prospective Studies
Statistics, Nonparametric
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Summary:Abstract Ferritin and paraoxonase-1 (PON-1) were measured in dogs experimentally infected by Leishmania infantum (during experimental infection and following treatment) and also in naturally-infected dogs which presented different degrees of proteinuria. Experimentally-infected dogs were monitored for 7 months post-infection, then treated for 3 months with allopurinol, and their response to therapy was followed for 11 additional months. Naturally-infected dogs were staged based on the urine protein/creatinine (UPC) ratio into three groups as follows: group 1 (non-proteinuric; UPC ratio: 0.5). An increase in serum ferritin values and a decrease in PON-1 activity were observed 2 months after infection. Both analytes returned to preinfection values following treatment. Significantly higher concentrations of ferritin were observed in dogs classified as either borderline or proteinuric when compared with non-proteinuric dogs whereas serum PON-1 activity was decreased only in proteinuric dogs.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2013.10.004