Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis

Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large‐scale proteomics screening. Unexpectedly, major compact myelin membrane prot...

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Bibliographic Details
Published in:Annals of neurology 2012-05, Vol.71 (5), p.601-613
Main Authors: Dhaunchak, Ajit Singh, Becker, Christopher, Schulman, Howard, De Faria Jr, Omar, Rajasekharan, Sathyanath, Banwell, Brenda, Colman, David R., Bar-Or, Amit
Format: Article
Language:English
Subjects:
Autoantigens - cerebrospinal fluid
Axons - metabolism
Axons - pathology
Biological and medical sciences
Biomarkers - cerebrospinal fluid
Child
Early Diagnosis
Female
Humans
Immunoblotting
Male
Mass Spectrometry
Medical sciences
Multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - pathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Myelin Proteins - cerebrospinal fluid
Nerve Tissue Proteins - cerebrospinal fluid
Neuroglia - metabolism
Neuroglia - pathology
Neurology
Ranvier's Nodes - metabolism
Ranvier's Nodes - pathology
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Summary:Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large‐scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon–glial interactions in those children destined for diagnosis of MS. Ann Neurol 2012;
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.22693